gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2 on tumor cells, is internalized, and releases an exatecan-derived topoisomerase I inhibitor (SHR9265), causing DNA damage, replication arrest, and apoptosis of the target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface tumor-associated antigen targeted by the ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06434103
disease_id_num_tar_ref
4475
drug_id_num_tar_ref
12090