gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 and recruits FcγR-expressing effector cells (e.g., NK cells) to kill target cells via ADCC; minor CDC/apoptosis may occur.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of HER2, blocking dimerization/activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04181333
disease_id_num_tar_ref
4478
drug_id_num_tar_ref
12098