gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells, triggering complement-dependent cytotoxicity and Fcγ receptor–mediated ADCC, and can induce apoptosis, leading to depletion of CD20+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds a conformational epitope on the large extracellular loop of CD20; IgG1 Fc mediates ADCC/CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06362967
disease_id_num_tar_ref
395
drug_id_num_tar_ref
1114