gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HLA-A*02:01–TP53 R175H peptide complex, become activated, and kill the antigen-positive cells via perforin/granzyme-mediated cytolysis (and related CTL effector mechanisms).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
allele-specific restriction; required for peptide presentation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05877599
disease_id_num_tar_ref
4484
drug_id_num_tar_ref
12110