gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD22, is internalized, and releases calicheamicin that binds DNA minor groove, causing double-strand breaks and apoptosis in the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell receptor internalized upon antibody binding, enabling intracellular delivery of calicheamicin
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06554626
disease_id_num_tar_ref
4493
drug_id_num_tar_ref
12143