gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DNA is not the targeted antigen. The ADC binds CD22, is internalized, then releases calicheamicin that binds DNA and causes double-strand breaks and apoptosis in CD22-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin binds the DNA minor groove in a sequence-specific manner and induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06554626
disease_id_num_tar_ref
4493
drug_id_num_tar_ref
12143