gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the tumor antigenic peptide–HLA-C complex via native TCRs and kill target cells through cytotoxic T-cell effector mechanisms (perforin/granzyme and Fas–FasL), with proinflammatory cytokines aiding apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
patient-specific peptide sequence; predominantly recognized by CD8+ TILs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05869539
disease_id_num_tar_ref
4494
drug_id_num_tar_ref
12147