gene_symbol
HLA-DRB1
hgnc_id
HGNC:4948
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs with native TCRs recognize the tumor antigenic peptide–HLA-DR (class II pMHC) on target cells and directly kill them via perforin/granzyme release and/or Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
patient-specific peptide sequence; recognized by CD4+ TILs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05869539
disease_id_num_tar_ref
4494
drug_id_num_tar_ref
12147