gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2 on tumor cells, is internalized, and releases MMAE; the payload then binds the Vinca site on beta‑tubulin to disrupt microtubules, causing G2/M arrest and apoptosis (with possible ADCC/bystander effects).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds the Vinca domain on beta-tubulin; multiple beta-tubulin isoforms may be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06155396
disease_id_num_tar_ref
4505
drug_id_num_tar_ref
12164