gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds the HER2 extracellular domain and engages Fcγ receptors on NK cells to trigger antibody‑dependent cellular cytotoxicity (ADCC), killing HER2+ cells; it may also activate complement-dependent cytotoxicity.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds subdomain IV of HER2 to inhibit dimerization and signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06537674
disease_id_num_tar_ref
4511
drug_id_num_tar_ref
12174