gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages FcγR+ effector cells (e.g., NK cells) to mediate ADCC against EGFR-expressing cells; EGFR/MET signaling blockade may also induce apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
receptor tyrosine kinase; extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05940116
disease_id_num_tar_ref
4514
drug_id_num_tar_ref
12180