gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CD19 on target cells, triggering T-cell activation and immunologic synapse formation, leading to perforin/granzyme-mediated apoptosis (and related T-cell cytotoxic pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen targeted by CAR scFv; HLA-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05715606
disease_id_num_tar_ref
4518
drug_id_num_tar_ref
12194