gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc strongly engages FcγRIIIa on NK cells and macrophages to drive ADCC and phagocytosis, and it also triggers direct, caspase-independent cell death of CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding to extracellular domain; mediates direct cell death and B-cell depletion.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06561360
disease_id_num_tar_ref
4522
drug_id_num_tar_ref
12207