gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
MSLN‑CAR T cells bind mesothelin on target cells and directly induce killing via T‑cell effector mechanisms (perforin/granzyme release and death‑receptor pathways), with co‑stimulatory/CD40 agonism enhancing activity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated cell-surface glycoprotein; CAR target antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05693844
disease_id_num_tar_ref
4528
drug_id_num_tar_ref
12226