gene_symbol
CD40
hgnc_id
HGNC:11919
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CD40 moiety is an agonist that activates/licenses APCs via CD40 to enhance T‑cell responses; killing is mediated by the MSLN‑CAR T cells against MSLN+ tumor cells, not against CD40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Agonist engagement to license/activate APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05693844
disease_id_num_tar_ref
4528
drug_id_num_tar_ref
12226