gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The co‑expressed costimulatory agonist activates T cells via their costimulatory receptors to boost CAR‑T function; cytotoxicity is directed by the CAR against mesothelin‑positive tumor cells (perforin/granzyme), not against cells expressing the costimulatory receptor.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Agonist to enhance T-cell activation, proliferation, and persistence; specific receptor not disclosed
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05693844
disease_id_num_tar_ref
4528
drug_id_num_tar_ref
12226