gene_symbol
PMEL
hgnc_id
HGNC:10880
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An ImmTAC with an affinity-enhanced TCR binds the gp100 peptide–HLA-A*02:01 complex on target cells and its anti-CD3 domain engages T cells, forming an immune synapse that activates T cells to kill the bound target cell via perforin/granzyme-mediated cytolysis (and related T cell effector mechanisms).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–HLA-A*02:01 complex on melanoma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06246149
disease_id_num_tar_ref
4529
drug_id_num_tar_ref
12230