gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and triggers Fc-mediated ADCC and ADCP, complement-dependent cytotoxicity (CDC), and direct pro-apoptotic signaling, leading to killing of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ecto-enzyme (NADase/ADPR cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05675319
disease_id_num_tar_ref
4532
drug_id_num_tar_ref
12245