gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Elotuzumab binds SLAMF7 on myeloma cells and its Fc engages FcγRIIIa on NK cells, triggering ADCC (and ADCP by macrophages), with NK activation via SLAMF7 further enhancing killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05675319
disease_id_num_tar_ref
4532
drug_id_num_tar_ref
12246