gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 via the CAR and directly kill target cells through perforin/granzyme-mediated lysis and death-receptor (Fas/FasL) apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual-target cCAR; binding to extracellular domain triggers CAR activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06787989
disease_id_num_tar_ref
4535
drug_id_num_tar_ref
12255