gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-expressing cells are recognized by the BCMA CAR on the engineered T cells, triggering T‑cell activation and killing via perforin/granzyme release and death-receptor (Fas/FasL) apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual-target cCAR; binding to extracellular domain triggers CAR activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06787989
disease_id_num_tar_ref
4535
drug_id_num_tar_ref
12255