gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax directly inhibits anti‑apoptotic BCL‑2 (BH3 mimetic), freeing pro‑apoptotic factors to activate BAX/BAK, causing mitochondrial outer membrane permeabilization, caspase activation, and apoptosis in BCL‑2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the hydrophobic BH3-binding groove; selective, spares BCL-XL (BCL2L1)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05791409
disease_id_num_tar_ref
401
drug_id_num_tar_ref
1128