gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Teclistamab engages CD3 on T cells to redirect them to BCMA+ myeloma cells; activated T cells kill BCMA-expressing cells via perforin/granzyme and cytokines. CD3+ T cells serve as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the CD3 complex; subunit commonly targeted is CD3 epsilon
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06208150
disease_id_num_tar_ref
4559
drug_id_num_tar_ref
12311