gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CTLA-4 on T cells (especially intratumoral Tregs) and engages Fcγ receptors on NK cells/macrophages to trigger ADCC/ADCP (and possibly CDC), depleting CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint receptor; also known as CD152
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06322108
disease_id_num_tar_ref
4566
drug_id_num_tar_ref
12337