gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC by immune effector cells (e.g., NK cells) against EGFR-expressing cells; may also engage complement (CDC). Signaling blockade is mainly antiproliferative.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain; ligand-blocking (EGF/TGF-α)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06413017
disease_id_num_tar_ref
4569
drug_id_num_tar_ref
12344