gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD22 CAR T cells bind CD22 on target cells, triggering CD3ζ/costimulatory signaling and T‑cell cytotoxicity via perforin/granzyme release, inducing apoptosis of CD22+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen on B-ALL blasts
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343090
disease_id_num_tar_ref
4580
drug_id_num_tar_ref
12384