gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and its Fc engages Fcγ receptors on NK cells and other effectors to mediate antibody-dependent cellular cytotoxicity (and phagocytosis), killing HER2-expressing cells; signaling blockade contributes but cytotoxicity is via ADCC.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05889988
disease_id_num_tar_ref
4581
drug_id_num_tar_ref
12386