gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on target cells and engages Fcγ receptor–bearing immune cells to mediate ADCC, killing HER2+ cells; HER2/HER3 signaling blockade can also induce apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II (dimerization arm) to block HER2/HER3 dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06276868
disease_id_num_tar_ref
404
drug_id_num_tar_ref
1139