gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Talquetamab binds CD3 on T cells to engage and activate them against GPRC5D-expressing tumor cells; T cells kill GPRC5D+ targets via perforin/granzyme, not CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
epsilon subunit of the TCR-CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06100237
disease_id_num_tar_ref
4586
drug_id_num_tar_ref
12394