gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages NK cells via its afucosylated Fc (high-affinity FcγRIIIa), triggering antibody-dependent cellular cytotoxicity that depletes IL-5Rα+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain on eosinophils and basophils; blocks IL-5 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06422078
disease_id_num_tar_ref
4588
drug_id_num_tar_ref
12397