gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages FcγRIIIa (CD16a) on NK cells via its afucosylated Fc to trigger ADCC; FcγRIIIa-expressing cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated Fc enhances affinity; mediates NK cell ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06422078
disease_id_num_tar_ref
4588
drug_id_num_tar_ref
12397