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gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-NK cells recognize CD19 and kill CD19-positive B cells via CAR-triggered NK cytotoxicity (perforin/granzyme). The common gamma chain is not a recognized target; it functions in IL-15 signaling to support NK activation and persistence, so cells expressing it are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-15 signals via IL2RG in complex with IL2RB on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06707259
disease_id_num_tar_ref
1
drug_id_num_tar_ref
1