gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on target cells, is internalized, and releases the SN-38 payload, a topoisomerase I inhibitor, causing DNA damage and apoptosis (with possible bystander killing from released SN-38).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC target antigen recognized by hRS7 antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05867251
disease_id_num_tar_ref
4594
drug_id_num_tar_ref
12419