gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Covalent, irreversible inhibition of mutant EGFR (T790M) blocks autophosphorylation and downstream MAPK/PI3K-AKT signaling, causing growth arrest and apoptosis of EGFR-mutant cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent EGFR kinase inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06417008
disease_id_num_tar_ref
4599
drug_id_num_tar_ref
12442