gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PSMA serves as a priming signal; its engagement induces expression of an anti‑CA9 CAR. Killing is mediated by the CA9 CAR (T‑cell cytotoxicity via perforin/granzyme) against CA9+ cells, not by PSMA recognition itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Priming/gating antigen recognized by a priming receptor to induce anti-CA9 CAR expression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06245915
disease_id_num_tar_ref
4602
drug_id_num_tar_ref
12448