gene_symbol
CA9
hgnc_id
HGNC:1383
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
PSMA engagement induces anti-CA9 CAR expression; the CAR T cells then recognize CA9 on tumor cells and directly lyse them via T-cell cytotoxic pathways (perforin/granzyme, death-receptor signaling).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Induced CAR target; CA9 CAR expression activated upon PSMA engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06245915
disease_id_num_tar_ref
4602
drug_id_num_tar_ref
12448