gene_symbol
FAS
hgnc_id
HGNC:11920
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Fas (CD95) is not a killing target; it is downregulated within the engineered T cells to prevent their apoptosis. The drug’s cytotoxicity is directed against PSMA/CA9-positive tumor cells via CAR-mediated T-cell killing, not against Fas-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
shRNA-miR knockdown in engineered T cells to prevent Fas-mediated apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06245915
disease_id_num_tar_ref
4602
drug_id_num_tar_ref
12448