gene_symbol
TGFBR2
hgnc_id
HGNC:11773
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TGF-βRII is not a kill target; it is knocked down within the engineered T cells to block TGF-β signaling. Killing is via induced anti-CA9 CAR activity against PSMA/CA9-positive tumor cells, not TGF-βRII–expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
shRNA-miR knockdown in engineered T cells to resist TGF-β–mediated immunosuppression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06245915
disease_id_num_tar_ref
4602
drug_id_num_tar_ref
12448