gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD19 ADC binds CD19, is internalized, and releases the PBD dimer tesirine via a cleavable linker; the payload forms DNA interstrand crosslinks (N2-guanine), inhibiting replication and killing CD19+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen; binding mediates ADC internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05600686
disease_id_num_tar_ref
4606
drug_id_num_tar_ref
12456