gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize the EGFR 806 epitope, form an immune synapse, and kill target cells via perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cryptic epitope exposed on amplified/overexpressed EGFR and EGFRvIII
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05168423
disease_id_num_tar_ref
4612
drug_id_num_tar_ref
12473