gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
LMB-100 binds mesothelin on target cells, is internalized, and its PE24 toxin ADP-ribosylates eEF2, halting protein synthesis and triggering apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored antigen; internalization mediates delivery of PE24 toxin
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05375825
disease_id_num_tar_ref
4622
drug_id_num_tar_ref
12497