gene_symbol
EEF2
hgnc_id
HGNC:3214
binding_type
other
cytotoxicity
NO
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
LMB-100 binds mesothelin on tumor cells, is internalized, and its PE24 toxin ADP-ribosylates eEF2 to block protein synthesis, inducing apoptosis; eEF2-expressing cells are not selectively targeted unless they express mesothelin.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
PE24 domain ADP-ribosylates eEF2 at the diphthamide residue to halt protein synthesis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05375825
disease_id_num_tar_ref
4622
drug_id_num_tar_ref
12497