gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2 on tumor cells, is internalized, and releases SN-38; SN-38 inhibits topoisomerase I, causing DNA damage and apoptosis. The membrane-permeable payload can also create a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein bound by the ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06235216
disease_id_num_tar_ref
4632
drug_id_num_tar_ref
12525