gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs use native TCRs to recognize the tumor-associated peptide on HLA class II and directly kill antigen-bearing cells via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–HLA class II (HLA-DR/DP/DQ; patient-specific allele); e.g., overexpressed self-antigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06532812
disease_id_num_tar_ref
4652
drug_id_num_tar_ref
12571