gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and engages Fcγ receptor–bearing immune cells (e.g., NK cells, macrophages) to mediate antibody-dependent cellular cytotoxicity; may also activate complement and induce apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of full-length HER2; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06130007
disease_id_num_tar_ref
4659
drug_id_num_tar_ref
12594