gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CD70 on target cells, activate, and kill via perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF superfamily ligand (CD27L/TNFSF7) on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06586658
disease_id_num_tar_ref
4670
drug_id_num_tar_ref
12624