gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds EGFR on tumor cells, is internalized, and releases a brengitecan topoisomerase I inhibitor that induces DNA damage and apoptosis; Fc-mediated ADCC/CDC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; bispecific ADC binding and internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06598787
disease_id_num_tar_ref
4677
drug_id_num_tar_ref
12642