gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD30, is internalized, then releases MMAE intracellularly; MMAE disrupts tubulin polymerization, causing G2/M arrest and apoptosis of CD30+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody binds CD30; complex is internalized and linker is cleaved to release MMAE.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05711628
disease_id_num_tar_ref
4681
drug_id_num_tar_ref
12651