gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets CD30, is internalized, and releases MMAE, which binds the Vinca site on beta-tubulin to block microtubule polymerization and cause G2/M arrest and apoptosis. Beta-tubulin expression alone is not sufficient; CD30-mediated delivery is required.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Released MMAE payload binds the Vinca domain on tubulin, blocking microtubule polymerization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05711628
disease_id_num_tar_ref
4681
drug_id_num_tar_ref
12651