gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-transduced T cells recognize the HLA-presented KRAS G12V peptide on tumor cells and kill them via perforin/granzyme-mediated cytotoxicity (apoptosis/lysis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex; codon 12 mutation; HLA class I or II restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253520
disease_id_num_tar_ref
4684
drug_id_num_tar_ref
12669